Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats
نویسندگان
چکیده
منابع مشابه
Tumor Necrosis Factor α - Mediated Increase in Nociceptors Excitability
Authors: 3 Sagi Gudes, Omer Barkai, Yaki Caspi, Ben Katz, Shaya Lev and Alexander 4 M. Binshtok 5 Author’s contribution: S.G. conducted the experiments and analyzed the data. O.B. 6 devised a computational model, Y.C. conducted the experiments, S.G., B.K., S.L. and 7 A.M.B. designed the experiments and wrote the manuscript. A.M.B. conceived the 8 study. 9 Affiliation: 10 1 Department of Medical...
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C-Fiber mechanoheat (C-MH) nociceptors from the saphenous nerve were studied, in control rats and in rats that underwent surgical sympathectomy. Intradermal injection, alone, of either norepinephrine (NE) or the calcium ionophore, A23187, did not affect mechanical threshold. The combination of A23187 and NE, however, significantly decreased mechanical threshold. In the presence of the alpha 2-a...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2010
ISSN: 0004-3591
DOI: 10.1002/art.27715